|
Older Anti-Psychotics Riskier for Elderly
NEW YORK - Older anti-psychotic drugs are no safer and might even be worse for the elderly than newer ones that the government warned about earlier this year — both raise the risk of death, a study suggests.
The Food and Drug Administration asked drug makers in April to add warnings to the labels of newer anti-psychotics because studies showed the drugs nearly doubled the risk of death for older patients with dementia.
These drugs are widely used to treat the aggressive behavior, delusions and hallucinations sometimes experienced by those with dementia, including Alzheimer‘s disease Alzheimer‘s disease.
The researchers analyzed prescription and death records for nearly 23,000 older patients who took anti-psychotics. They found that 18 percent of patients on the old drugs died in the first six months, compared with 15 percent on the new drugs.
"If confirmed, our results suggest that conventional anti-psychotic medications should be included in the FDA‘s public health advisory," the researchers said. Their findings appear in Thursday‘s New England Journal of Medicine .
"All we can do is encourage clinicians to be thoughtful — to balance whatever benefits there are with what appears to be risk," Wang said.
William Thies, scientific director of the Alzheimer‘s Association, said he has not seen any evidence that doctors are switching to the older drugs. One of the concerns with the older drugs, he said, is their more severe side effects, including Parkinson‘s-like tremors and involuntary movements.
The newer anti-psychotics, such as Risperdal and Seroquel, came out in the 1990s and now account for 95 percent of the prescriptions for anti-psychotics, according to IMS Health, a pharmaceutical information and consulting company.
The study, using information from a Pennsylvania prescription program, looked at 22,890 people over 65 who began taking anti-psychotics between 1994 and 2003. Taking into account age, illnesses and other factors, the researchers calculated that those on the older drugs had a 37 percent higher risk of death. The risk was highest for those on higher doses and during the first 40 days of use.
|
