Anti-Aging-Meds.com

Selegilin

Selegiline protects against aging of the brain, enhances mental function. A powerful remedy against Parkinson's disease, Selegiline is effective also as an antidepressant and as a protector against Alzheimer's disease. Professor Knoll, who developed Selegiline is convinced of its anti-aging effect and recommends for this a dose 5 mg per week (in two doses of 2.5 mg each). Packing: Box of 30 tablets, 5 mg

Medications and Prescriptions

Generic name: Deprenyl
Product Brand Name: Eldepryl ®, Selegeline ®

1. Description: Selegiline works by helping to conserve the amount of dopamine available by preventing the dopamine from being destroyed. While controversial, there is some evidence that this drug may slow the progression of Parkinson's disease, particularly early in the course of the disease. This drug is well-tolerated by most people, so many experts recommend using it despite the controversies.

2. Doxycycline is Prescribed for: Selegiline is used to treat Parkinson's disease. Parkinson's disease is associated with low levels of a chemical called dopamine (doe PA meen) in your brain. The exact way that Selegiline works is unknown. However, it is believed that Selegiline prevents the breakdown of dopamine in your brain. Selegiline is usually added to a treatment regimen after levodopa / carbidopa therapy begins to deteriorate.

Selegiline is also used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It is also used to treat the same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), and others.
Selegiline may also be used for purposes other than those listed in this medication guide.

3. Drug Mechanism: Selegiline provides selective protection against the age-related degeneration of the dopaminergic nervous system. It protects sensitive dopamine-containing neurons from the age-associated increases in glial cells (non-neuron brain cells) and the monoamine oxidase (type B) that they contain. Selegiline is the first selective inhibitor of MAO-B ever discovered, it is the only one used in clinical practice, and it remains the scientific reference standard for B-type inhibition after more than 40 years.

Selegiline also competitively inhibits the uptake of dopamine, norepinephrine and epinephrine (collectively referred to as catecholamines) into neurons. This unique ability among the MAO inhibitors prevents the “cheese effect,” a dangerous hypertensive reaction caused by neural uptake of tyramine from tyramine-containing foods like aged cheeses, certain wines, yeast, beans, chicken liver and herring. Selegiline exhibits no significant cheese effect at therapeutic dosages, and only minimal effects at extremely high dosages.

Selegiline is a drug that was discovered around 1964-65. It was originally developed as a “psychic energizer,” designed to integrate some amphetamine-like brain effects with antidepressant effects. Also known as L-deprenyl, (-)-deprenyl, and selegiline, Selegiline has been intensively researched over the past 36 years - many hundreds of research papers on Selegiline have been published. Selegiline has been shown to protect nerve cells against a wide (and growing) number of neurotoxins. Selegiline has also been shown to be a “neuroprotection/ neurorescue agent” when nerve cells are exposed to damaging or stressful conditions.

4. Dosage Form: The dose of Selegiline will be different for different patients. Your doctor will determine the proper dose of Selegiline for you. Follow your doctor's orders or the directions on the label.

For the treatment of Parkinson's disease, the usual dose of Selegiline is 5 mg two times a day, taken with breakfast and lunch. Some patients may need less than this.

5. Drug Interactions: Selegiline can interact with other medications such as Demerol, and many depression medications. Be sure to talk to your doctor about any other medication you are taking before taking Selegiline. Although Selegiline is less likely than non-selective monoamine oxidase inhibitors to interact with tyramine in food, like other monoamine oxidase inhibitors it can produce life-threatening reactions when given with pethidine. Zornberg GL, et al. severe adverse interaction between pethidine and Selegiline.

6. Pregnancy: Selegiline has not been studied in pregnant women. However, this medicine has not been shown to cause birth defects or other problems in animal studies.

7. Nursing Mothers: is not known whether Selegiline passes into the breast milk.

8. Dietary and Alcohol Considerations: Alcoholic beverages or alcohol-free or reduced-alcohol beer and wine.
Foods that have a high tyramine content (most common in foods that are aged or fermented to increase their flavor), such as cheeses; fava or broad bean pods; yeast or meat extracts; smoked or pickled meat, poultry, or fish; fermented sausage (bologna, pepperoni, salami, summer sausage) or other fermented meat; sauerkraut; or any overripe fruit. If a list of these foods and beverages is not given to you, ask your health care professional to provide one.

9. Possible Side Effects: Common side effects are nausea and vomiting. The most frequent side effects also include chest pain (severe); enlarged pupils; fast or slow heartbeat; headache (severe); increased sensitivity of eyes to light; increased sweating (possibly with fever or cold, clammy skin); nausea and vomiting (severe); stiff or sore neck.

10. Storage: Keep this medication in the container it came in, tightly closed, and out of reach of children. Selegiline should be stored at below 30°C (86°F) and away from excess heat and moisture (not in the bathroom). Heat or moisture may cause the medicine to break down. Keep away from light. Talk to your pharmacist about the proper disposal of your medication. Throw away any medication that is outdated or no longer needed. Be sure that any discarded medicine is out of the reach of children.

11. Package Size and Type: Tablets: 5 mg, 10 mg.

Selegiline notes:

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The drug deprenyl is sold under different brand names namely eldepryl, selegiline, and jumex. Selegiline enhances the brain and improves your mental capabilities. Selegiline can be prescribed for Parkinson’s. Instead of selegiline you can also buy eldepryl. Selegiline can protect you from Alzheimer’s disease. Selegiline can be taken as an antidepressant. Selegiline helps to preserve the dopamine in the brain by preventing it from being reduced. Your pet dog too can be prescribed selegiline for dogs by the vet.

You are advised to ask the doctor about dietary restrictions. Alcohol, fermented and aged food, pickles, fermented sausages, pepperoni, and overripe food should be avoided when taking selegiline. Pregnant women and nursing mothers should consult their doctors before taking selegiline. No problems have been reported but it is best to take the advice of the doctor. Selegiline should not be taken with other depression medications. Tell your doctor about any medicines that you are taking before selegiline is prescribed to you. Some side effects of selegiline include nausea, vomiting, chest pain, and headache. Some other side effects of selegiline are enlarged pupils, varied heartbeat, over sensitivity to light, sweating in the body, selegiline depression and stiff neck.

The amount of selegiline required will be different for different persons. Your doctor will be able to guide you regarding the dosage depending on your condition. Normally Parkinson’s patients are prescribed 5 mg two times a day along with breakfast and lunch. Some doctors would prescribe less amounts of selegiline. As you age you can have functional slowdown due to slow down in protein oxidation. For anti aging benefits of Selegiline you can take 5 mg of selegiline per week as two doses of 2.5 mg each. Alternatively you can also take eldepryl 5 for anti aging. Remember to take selegiline, eldepryl, or jumex deprenyl with a meal. Eldepryl for depression is commonly used by people nowadays.

Caution! Before starting to take this medicine, it is vital that you should consult your doctor! Do not use it on your own initiative, without medical advice.